ESM Cambrian is a next generation language model trained on protein sequences at the scale of life on Earth. ESM C models define a new state of the art for protein representation learning.
ESM C models are a parallel model family to our flagship ESM3 generative models for programmable protein engineering. While ESM3 focuses on controllable generation of proteins for therapeutic and many other applications, ESM C focuses on creating representations of the underlying biology of proteins. ESM C scales up data and training compute to deliver dramatic performance improvements over ESM2.
Highlights
The 300M version of ESM Cambrian; a protein language model that defines a new state of the art for protein representation learning.
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This listing is free to use, so the four dimensions carry no software charge. Each dimension reflects a way to run model inference on AWS SageMaker, billed by host hours. You pick between two instance sizes: ml.g5.2xlarge or ml.g5.4xlarge. For each size, you also choose a mode: batch or real-time. Batch mode processes grouped requests, while real-time mode handles live requests. Your cost depends on which instance size and mode you select, plus how many hours you run it.
Top-of-mind questions for buyers
What resources do I get with each ml.g5.2xlarge or ml.g5.4xlarge host hour?
You pay for the AWS SageMaker instance that runs model inference. The ml.g5.2xlarge and ml.g5.4xlarge are GPU-backed instance types, with the ml.g5.4xlarge providing more compute and memory. You are billed per host hour the instance runs, regardless of how many requests it processes.
Am I charged when the instance sits idle or when I stop it?
Billing is per host hour the instance runs. This software listing is free, so no software charge applies. Real-time endpoints accrue AWS instance charges while active, even when idle. Batch jobs run only for the duration of the task. Stopping the instance ends host-hour charges.
How does batch mode differ from real-time mode for my bill?
Batch mode processes grouped requests, so the instance runs only during the job and stops afterward. Real-time mode keeps an endpoint running to handle live requests, accruing host hours the whole time it stays up. Batch suits scheduled workloads; real-time suits continuous, on-demand inference.
evolutionaryscale.ai
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An Amazon SageMaker model package is a pre-trained machine learning model ready to use without additional training. Use the model package to create a model on Amazon SageMaker for real-time inference or batch processing. Amazon SageMaker is a fully managed platform for building, training, and deploying machine learning models at scale.
Deploy the model on Amazon SageMaker AI using the following options:
Real-time inference
Deploy the model as an API endpoint for your applications. When you send data to the endpoint, SageMaker processes it and returns results by API response. The endpoint runs continuously until you delete it. You're billed for software and SageMaker infrastructure costs while the endpoint runs. AWS Marketplace models don't support Amazon SageMaker Asynchronous Inference. For more information, see Deploy models for real-time inference .
Batch transform
Deploy the model to process batches of data stored in Amazon Simple Storage Service (Amazon S3). SageMaker runs the job, processes your data, and returns results to Amazon S3. When complete, SageMaker stops the model. You're billed for software and SageMaker infrastructure costs only during the batch job. Duration depends on your model, instance type, and dataset size. AWS Marketplace models don't support Amazon SageMaker Asynchronous Inference. For more information, see Batch transform for inference with Amazon SageMaker AI .
Version release notes
Bugfixes: reduce gpu imprecision, fix list encoding bug
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