Sold by: Sage Bionetworks
Open data
|
Deployed on AWS
The MIT ROSMAP Single-Nucleus Multiomics Study provides single-nucleus
transcriptomic and chromatin accessibility data generated from postmortem
brain tissue from participants in the Religious Orders Study and Rush Memory
and Aging Project (ROSMAP). The study includes single-nucleus RNA sequencing,
single-nucleus ATAC sequencing, and paired multiome data from 427 prefrontal
cortex samples, as well as single-nucleus RNA sequencing data from multiple
brain regions. These data support investigation of cell-type-specific
molecular changes, cellular vulnerability, cognitive resilience, and
Alzheimer's disease progression.
Overview
The MIT ROSMAP Single-Nucleus Multiomics Study provides single-nucleus transcriptomic and chromatin accessibility data generated from postmortem brain tissue from participants in the Religious Orders Study and Rush Memory and Aging Project (ROSMAP). The study includes single-nucleus RNA sequencing, single-nucleus ATAC sequencing, and paired multiome data from 427 prefrontal cortex samples, as well as single-nucleus RNA sequencing data from multiple brain regions. These data support investigation of cell-type-specific molecular changes, cellular vulnerability, cognitive resilience, and Alzheimer's disease progression.
Features and programs
Open Data Sponsorship Program
This dataset is part of the Open Data Sponsorship Program, an AWS program that covers the cost of storage for publicly available high-value cloud-optimized datasets.
Pricing
This is a publicly available data set. No subscription is required.
Legal
Content disclaimer
Vendors are responsible for their product descriptions and other product content. AWS does not warrant that vendors' product descriptions or other product content are accurate, complete, reliable, current, or error-free.
Delivery details
AWS Data Exchange (ADX)
AWS Data Exchange is a service that helps AWS easily share and manage data entitlements from other organizations at scale.
Open data resources
Available with or without an AWS account.
- How to use
- To access these resources, reference the Amazon Resource Name (ARN) using the AWS Command Line Interface (CLI). Learn more
- Description
- This study provides controlled-access single-nucleus RNA sequencing, single-nucleus ATAC sequencing, paired RNA and chromatin-accessibility multiome data, and related metadata generated from postmortem brain tissue from ROSMAP participants.
- Resource type
- S3 bucket
- Amazon Resource Name (ARN)
- arn:aws:s3:::mit-rosmap.opendata.sagebase.org
- AWS region
- us-east-1
- AWS CLI access (No AWS account required)
- aws s3 ls --no-sign-request s3://mit-rosmap.opendata.sagebase.org/
Resources
Vendor resources
Support
Managed By
Sage Bionetworks
How to cite
The MIT ROSMAP Single-Nucleus Multiomics Study (MIT_ROSMAP_Multiomics) was accessed on DATE from https://registry.opendata.aws/mit-rosmap .
Similar products
At the Knowledge Portal Network, we aggregate and analyze genetic association results for a wide range of diseases and traits. For any given disease, a large number of individual genetic association datasets may have been generated. To make these results more interpretable, we meta-analyze all datasets for each phenotype, using a method that we term "bottom-line integrative analysis". Here we provide the bottom-line summary statistic files for public download.
This release contains information on the precinct-level returns for the United States Senate elections in each of the fifty states of the United States for the year of 2016. Precinct-level elections are the smallest component in which electoral districts are divided into.
This dataset contains a diverse range of imaging biological data and models. The data is sourced and curated by a team of experts at CZI and is made available as part of these datasets only when it is not publicly accessible or requires transformations to support model training.
Aging is a major risk factor for neurodegenerative diseases, yet underlying epigenetic mechanisms remain unclear. Here, we generated a comprehensive single-nucleus cell atlas of brain aging across multiple brain regions, comprising 132,551 single-cell methylomes and 72,666 joint chromatin conformation-methylome nuclei. Integration with companion transcriptomic and chromatin accessibility data yielded a cross-modality taxonomy of 36 major cell types.