Allen Institute for Neural Dynamics - Extracellular Electrophysiology Compression Benchmark

This is a large-scale survey that describes the physiology (strength, kinetics, and short term plasticity) of thousands of synapses from patch clamp experiments in mouse visual cortex and human middle temporal gyrus.

The Allen Institute for Neural Dynamics (AIND) is committed to FAIR, Open, and Reproducible science. We therefore share all of the raw and derived data we collect publicly with rich metadata, including preliminary data collected during methods development, as near to the time of collection as possible.

The Allen Brain Observatory – Visual Coding is a large-scale, standardized survey of physiological activity across the mouse visual cortex, hippocampus, and thalamus. It includes datasets collected with both two-photon imaging and Neuropixels probes, two complementary techniques for measuring the activity of neurons in vivo. The two-photon imaging dataset features visually evoked calcium responses from GCaMP6-expressing neurons in a range of cortical layers, visual areas, and Cre lines. The Neuropixels dataset features spiking activity from distributed cortical and subcortical brain regions, collected under analogous conditions to the two-photon imaging experiments. We hope that experimentalists and modelers will use these comprehensive, open datasets as a testbed for theories of visual information processing.

This dataset consists of images of glioblastoma human brain tumor tissue sections that have been probed for expression of particular genes believed to play a role in development of the cancer. Each tissue section is adjacent to another section that was stained with a reagent useful for identifying histological features of the tumor. Each of these types of images has been completely annotated for tumor features by a machine learning process trained by expert medical doctors.